Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (sleep apnea).XYREM can cause serious side effects, including the following: Those activities should not be done until you know how XYREM affects you or your child.įalling asleep quickly, including while standing or while getting up from the bed, has led to falls with injuries that have required some people to be hospitalized. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.Īnyone who takes XYREM should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least 6 hours after taking XYREM. Selling or giving away XYREM may harm others, and is against the law. Keep XYREM in a safe place to prevent abuse and misuse. You or your child must be enrolled in the XYWAV and XYREM REMS to receive XYREM.ĭo not take XYREM if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drink alcohol, or have a rare problem called succinic semialdehyde dehydrogenase deficiency. Call your doctor right away if you or your child has any of these serious side effects.īecause of these risks, you have to go through the XYWAV and XYREM REMS. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Abuse or misuse of illegal GHB alone or with other CNS depressants (drugs that cause changes in alertness or consciousness) have caused serious side effects. The active ingredient of XYREM is a form of gamma hydroxybutyrate (GHB). WARNING: Taking XYREM with other Central Nervous System (CNS) depressants such as medicines used to make you or your child fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

Cataplexy attack